Quantitative MRI-markers are essential for monitoring disease progression in late-onset pompe disease (LOPD). Using muscle diffusion tensor imaging (mDTI) and mDixon we evaluated differences in diffusion parameters in six thigh and seven calf muscles - with <10% and >10% fat-fraction - of 18 LOPD and 29 healthy controls (HC). Upper leg muscles with <10% fat-fraction showed significant differences in MD, RD, λ1-3 and MD positively correlated with 6-MWT (p=0.003). mDTI reveals an increased diffusion restriction in muscles of LOPD-patients with and without fat-infiltration and could reflect structural changes prior to fatty degeneration.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords