Rheumatoid arthritis can present with the loss of muscle mass and a decrease in strength and functional capability. This study demonstrates that Quantitative MRI can detect differences in the muscles of RA patients, whether they are newly diagnosed, in remission or with persistently active disease. Differences in T2, FF and muscle volume were apparent at diagnosis, suggesting muscle changes in RA occur early. Furthermore, despite RA treatment, patients in remission show worse MRI parameters and strength compared to healthy individuals, suggesting the muscles have pathology. This warrants attention in improving the muscle health throughout the spectrum of the RA continuum.
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