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Abstract #2727

Diffusion tensor imaging of articular cartilage at 3T: repeatability and sensitivity to degenerative changes

Valentina Mazzoli1, Lauren Elizabeth Watkins1, Elka Brooke Rubin1, Brian Hargreaves1, Feliks Kogan1, and Garry Evan Gold1
1Department of Radiology, Stanford University, Stanford, CA, United States

Mean Diffusivity (MD) and Fractional Anisotropy (FA) derived from DTI are a very promising biomarker of cartilage health. Many current implementations of DTI require high field scanners, and its feasibility utility at 3T is unclear. The aim of this study was to develop an optimized DTI acquisition and postprocessing protocol for the evaluation of femoral articular cartilage at 3T in a clinically feasible scan time, and to assess its repeatability and sensitivity to transient changes induced by exercise. Our results show that MD and FA measurements at 3T are repeatable and robust to changes induced by exercise.

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