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Abstract #2730

Scan-Rescan Variability and Left-Right Knee Asymmetry of Cartilage Morphometry Assessed with Rapid MRI in a Harmonized Multi-Vendor Study

Akshay Chaudhari1, Quin Lu2, Anna Wisser3,4, Wolfgang Wirth3,4, Garry E Gold1, Brian A Hargreaves1, and Felix Eckstein3,4
1Stanford University, Stanford, CA, United States, 2Philips, San Francisco, CA, United States, 3Paracelsus Medical University, Salzburg, Austria, 4Chondrometrics GmbH, Ainring, Germany

Changes in cartilage morphology have shown to predict and monitor osteoarthritis progression with great sensitivity. However, the lack of a rapid and inexpensive MRI technique for imaging cartilage that can be implemented across vendors is a challenge in large multi-site clinical studies. In this work, we evaluate multi-vendor and scan-rescan reliability and explore left-right knee asymmetries of cartilage morphology measured using a rapid, 4-minute quantitative double-echo steady-state (qDESS) sequence. We demonstrate qDESS harmonization across vendors, which can produce high scan-rescan repeatability and high repeatability of left-right knee asymmetry of cartilage volume, surface area, and thickness metrics.

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