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Abstract #2743

Distinguishing Exercise-Induced Compositional Changes in Knee Cartilage with Quantitative MR Relaxation Time Mapping

Dimitri A Kessler1, Joshua D Kaggie1, James W MacKay1,2, Scott McDonald3, Andrew Grainger1, Alexandra R Roberts4, Robert L Janiczek5, Martin J Graves1, and Fiona J Gilbert1
1Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 2Norwich Medical School, University of East Anglia, Norwich, United Kingdom, 3Cambridge University Hospitals NHS Foundation Trust, Addenbrooke’s Hospital, Cambridge, United Kingdom, 4Independent Clinical Imaging Consultant, Munich, Germany, 5GlaxoSmithKline, Clinical Imaging, Philadelphia, PA, United States

We introduce a method to reliably determine changes in healthy knee cartilage composition after joint loading. Ten healthy participants were imaged before and after participant repositioning to determine the test-retest repeatability of T1ρ and T­2 relaxation time mapping. Additionally, nine healthy participants were imaged before and after a mild, dynamic stepping exercise. Three-dimensional surface analysis of patellar, femoral, and lateral and medial tibial cartilage was performed. The exercise surface data was thresholded with the determined measurement errors from the T1ρ and T­2 repeatability data to highlight cartilage regions experiencing reliable exercise-induced compositional changes.

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