Abstract #2749

Inhomogenous Magnetization Transfer Imaging in Cartilage – Initial Demonstration and Protocol Optimization at 7 Tesla

Andrew C. Yung¹, Valentin H. Prevost¹, Jane Desrochers², David Wilson², and Piotr Kozlowski¹

¹UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, ²Centre for Hip Health and Mobility, University of British Columbia, Vancouver, BC, Canada

This work presents one of the first examples of ihMT imaging in cartilage, using ex vivo bovine knee specimens at 7 Tesla. Protocol optimization experiments were performed to determine the optimal set of parameters (B_1rms, TR, frequency offset, centre frequency) to maximize the ihMTRex signal. Cartilage-specific signal was observed, which may be related to residual dipolar order established by the highly ordered nature of collagen.

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