Despite the fact that diffusion MRI is well established in bone marrow as a valuable imaging modality, only a limited number of studies have investigated the intravoxel incoherent motion (IVIM) approach. In this study, bi-exponential IVIM was used to measure diffusion and perfusion fraction in lumbar vertebral bone marrow in 99 healthy subjects. The results demonstrated a gender-related variation in D and f while D* was an independent factor. Our findings may help to better understand the variation of water diffusion and perfusion imaging in lumbar vertebral bone marrow in-vivo with healthy and pathological condition.
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