This study deals with assessing the ability of current clinical measures of bone to model the systematic age-related alteration of bone during aging and where does MRI stand as a new modality. Fifty Healthy volunteers with an average age of 44.53 ±7.95 were enrolled based on oral interviews and blood tests. Quantitative measurements were performed by various modalities for lumbar spine, forearm (DXA), Calcaneus (QUS), and Tiba (QCT and MRI). Pearson correlation coefficients was calculated between the bone parameters and age. The highest correlation coefficient between bone parameters and age was related to T1 (r = 0.766, p <0.01).