Abstract #2781

Evaluation of Gadolinium Deposition in Cortical Bone Using 3D-UTE-QSM in vitro: Preliminary Study

Xiaodong Zhang^1,2, Hyungseok Jang², Yanjun Chen^1,2, Zhenyu Cai², Ya-Jun Ma², Wei Zhao², Yanqiu Feng³, and Jiang Du²

¹Department of Radiology, Third Affiliated Hospital of Southern Medical University, Guangzhou, China, ²Department of Radiology,University of California San Diego, San Diego, CA, United States, ³School of Biomedical Engineering, Southern Medical University, Guangzhou, China

After injection of gadolinium-based contrast agents (GBCAs) for enhanced magnetic resonance imaging (MRI), levels of gadolinium (Gd) in the brain are much lower than that measured in bone. The 3D ultrashort echo time Cones Quantitative susceptibility mapping (3D UTE-Cones-QSM) technique has been used to assess calcium in cortical bone. In this study, we investigated the feasibility of evaluating gadolinium deposition in cortical bone in vitro using 3D UTE-Cones-QSM on a 3T clinical scanner. Higher QSM values were observed with higher Gd concentrations, indicating that 3D UTE-Cones-QSM could be a new, non-invasive technique for evaluation of Gd deposition in bone.

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