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Abstract #2798

 AcidoCEST-UTE MRI is a Reproducible Method to Measure Cartilage and Meniscus pH

Rachel A High1,2, Yang Ji1, Ya-Jun Ma1, Qingbo Tang2, Mark E Murphy3, Jiang Du1, and Eric Y Chang1,2
1Radiology, University of California San Diego, San Diego, CA, United States, 2Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States, 3Orthopedic Surgery Service, VA San Diego Healthcare System, San Diego, CA, United States

The acidification of musculoskeletal tissues is being investigated as a way to localize pain in osteoarthritis. AcidoCEST-UTE MRI can measure pH in tissues such as cartilage and meniscus, though in vivo validation is difficult. Thus, it is imperative that the acidoCEST-UTE sequence be reproducible and verifiable ex vivo, where pH measurements can be confirmed with a pH electrode. This study tested the reproducibility of the acidoCEST-UTE sequence in three ex vivo phantoms, confirming the pH sensitivity of the technique and demonstrating the consistency of the method and results.

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