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Abstract #2809

Ultrashort echo time adiabatic T1ρ (UTE-Ad-T1ρ) can predict the mechanical property differences in human anterior cruciate ligament (ACL)

Saeed Jerban1, Takehito Hananouchi2, Yajun Ma1, Erik Dorthe3, behnam namiranian1, Jonathan Wong4, Mei Wu1, Darryl D'lima3, Eric Y Chang4, and Jiang Du1
1Radiology, University of California, San Diego, San Diego, CA, United States, 2Department of Mechanical Engineering, Osaka Sangyo University, Daito, Osaka, Japan, 3Shiley Center for Orthopedic Research and Education at Scripps Clinic, La Jolla, CA, United States, 4Research Service, VA San Diego Healthcare System, San Diego, CA, United States

Clinical MRI techniques typically show the anterior cruciate ligament (ACL) as low in signal. Commonly used quantitative MRI techniques are sensitive to tissue orientation and magic angle effect. A recently developed ultrashort echo time (UTE)-based adiabatic T1ρ technique (UTE-Ad-T1ρ) can detect high signal in the ACL and may be less sensitive to magic angle effect. We have investigated for the first time the correlation between UTE-Ad-T1ρ and ACL mechanical properties. T1ρ showed significant strong correlation with average elastic modulus of ACL specimens. The UTE-Ad-T1ρ technique is highlighted as a potential tool to noninvasively assess the ACL mechanical properties.

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