Abstract #2809

Ultrashort echo time adiabatic T1ρ (UTE-Ad-T1ρ) can predict the mechanical property differences in human anterior cruciate ligament (ACL)

Saeed Jerban¹, Takehito Hananouchi², Yajun Ma¹, Erik Dorthe³, behnam namiranian¹, Jonathan Wong⁴, Mei Wu¹, Darryl D'lima³, Eric Y Chang⁴, and Jiang Du¹

¹Radiology, University of California, San Diego, San Diego, CA, United States, ²Department of Mechanical Engineering, Osaka Sangyo University, Daito, Osaka, Japan, ³Shiley Center for Orthopedic Research and Education at Scripps Clinic, La Jolla, CA, United States, ⁴Research Service, VA San Diego Healthcare System, San Diego, CA, United States

Clinical MRI techniques typically show the anterior cruciate ligament (ACL) as low in signal. Commonly used quantitative MRI techniques are sensitive to tissue orientation and magic angle effect. A recently developed ultrashort echo time (UTE)-based adiabatic T1ρ technique (UTE-Ad-T1ρ) can detect high signal in the ACL and may be less sensitive to magic angle effect. We have investigated for the first time the correlation between UTE-Ad-T1ρ and ACL mechanical properties. T1ρ showed significant strong correlation with average elastic modulus of ACL specimens. The UTE-Ad-T1ρ technique is highlighted as a potential tool to noninvasively assess the ACL mechanical properties.

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