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Abstract #2829

A rat model of periprosthetic joint infection (PJI) using 3D printed titium hip implants:  Ultrashort echo time (UTE) MRI at 7T

Mariam Taha1,2, Greg O. Cron1,3,4, Gerd Melkus3,4, Peder E.Z. Larson5, Mazen Ibrahim2, Adam D.M. Paish6,7, Yusra Al Mosuli1,2, William Hadden2, David Holdsworth6,7, and Hesham Abdelbary2
1Ottawa Hospital Research Institute, Ottawa, ON, Canada, 2Orthopedic Surgery, The Ottawa Hospital, Ottawa, ON, Canada, 3Medical Imaging, The Ottawa Hospital, Ottawa, ON, Canada, 4Radiology, University of Ottawa, Ottawa, ON, Canada, 5Radiology, University of California at San Francisco, San Francisco, CA, United States, 6Western University, London, ON, Canada, 7Robarts Research Institute, London, ON, Canada

Two to fourteen percent of primary total joint replacement cases develop periprosthetic joint infection (PJI), a devastating complication. PJI animal models for hip and knee are required to evaluate prevention and treatment methods. We developed a novel rat model for PJI using a 3D printed titanium hip implant. Implant stability in the rats was monitored with 7T MRI using Ultrashort Echo Time (UTE) imaging and classical spin echo imaging. UTE demonstrated superior image quality compared to spin echo imaging. This rat model will provide a unique opportunity to validate and study strategies focusing on the prevention and treatment of PJI.

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