Abstract #2829

A rat model of periprosthetic joint infection (PJI) using 3D printed titium hip implants: Ultrashort echo time (UTE) MRI at 7T

Mariam Taha^1,2, Greg O. Cron^1,3,4, Gerd Melkus^3,4, Peder E.Z. Larson⁵, Mazen Ibrahim², Adam D.M. Paish^6,7, Yusra Al Mosuli^1,2, William Hadden², David Holdsworth^6,7, and Hesham Abdelbary²

¹Ottawa Hospital Research Institute, Ottawa, ON, Canada, ²Orthopedic Surgery, The Ottawa Hospital, Ottawa, ON, Canada, ³Medical Imaging, The Ottawa Hospital, Ottawa, ON, Canada, ⁴Radiology, University of Ottawa, Ottawa, ON, Canada, ⁵Radiology, University of California at San Francisco, San Francisco, CA, United States, ⁶Western University, London, ON, Canada, ⁷Robarts Research Institute, London, ON, Canada

Two to fourteen percent of primary total joint replacement cases develop periprosthetic joint infection (PJI), a devastating complication. PJI animal models for hip and knee are required to evaluate prevention and treatment methods. We developed a novel rat model for PJI using a 3D printed titanium hip implant. Implant stability in the rats was monitored with 7T MRI using Ultrashort Echo Time (UTE) imaging and classical spin echo imaging. UTE demonstrated superior image quality compared to spin echo imaging. This rat model will provide a unique opportunity to validate and study strategies focusing on the prevention and treatment of PJI.

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