Abstract #2849

Learning MR-guided PET reconstruction in image space using a convolutional neural network - application to multiple PET tracers

Georg Schramm¹, David Rigie², Thomas Vahle³, Ahmadreza Rezaei¹, Koen van Laere¹, Timothy Shepherd⁴, Johan Nuyts¹, and Fernando Boada²

¹Department of Imaging and Pathology, Division of Nuclear Medicine, KU Leuven, Leuven, Belgium, ²Center for Advanced Imaging Innovation and Research (CAI2R) and Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York City, NY, United States, ³Siemens Healthcare GmbH, Erlangen, Germany, ⁴Department of Neuroradiology, NYU Langone Health, Department of Radiology, New York University School of Medicine, New York City, NY, United States

Recently, we could show that MR-guided PET reconstruction can be mimicked in image space using a convolutional neural network which facilitates the translation of MR-guided PET reconstructions into clinical routine. In this work, we test the robustness of our CNN against the used input PET tracer. We show that training the CNN with PET images from two different tracers ([¹⁸F]FDG and [¹⁸F]PE2I), leads to a CNN that also performs very well on a third tracer ([¹⁸F]FET) which was not the case when the network was trained on images from one tracer only.

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