Most clinical MRS studies concentrate on the upfield part of the spectrum, neglecting the downfield region, since it is mainly composed of labile protons with intensities depending on the water suppression scheme. For reliable and sensitive quantification, a non-water-suppressed or even better a non-water-excitation (NWE) technique is required.
We introduce a non-echo technique based on ISIS localization for optimal detection of (moderately) fast exchanging protons at 3T with minimal signal loss due to T2 or exchange and with optimized water magnetization path for longitudinal relaxation enhancement.
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