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Abstract #2882

Five-minute GABA: Halving the scan time of GABA-edited MRS measurements

Mark Mikkelsen1,2 and Richard A. E. Edden1,2
1Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Measurement of lower-concentration metabolites at ≤3T using edited MRS requires relatively long scan times (~10 min for a 27-mL voxel). We investigated whether scan times can be halved to ~5 min without a significant increase in group-level variance. GABA-edited MEGA-PRESS data from the Big GABA repository were analyzed by quantifying GABA+/Cr levels for complete datasets (320 averages; ~10 min) versus the first half of each (160 averages; ~5 min). There were no significant differences in group-level variance or GABA+/Cr levels. It appears that for a large, high-SNR voxel, GABA editing scan times of ~5 min are feasible.

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