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Abstract #2884

Simultaneous Measurement of Glutamate, Glutamine, and Glutathione by Single-Step Spectral Editing

Li An1, Maria Ferraris Araneta1, Milalynn Victorino1, and Jun Shen1
1National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States

A single-step spectral editing MRS sequence is described for simultaneously measuring glutamate, glutamine, and glutathione at 7 T. Same as a previously described three-step editing technique, the editing pulse induces the collapse of targeted multiplets into high intensity pseudo singlets at a medium echo time. No data subtraction is necessary. In the current example, the editing pulse acts on the H3 protons of glutamate, glutamine, and glutathione near 2.12 ppm to generate sharp and high intensity pseudo singlets of glutamate, glutamine, and glutathione H4 protons. Signal enhancement of the three metabolites is analyzed in detail.

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