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Abstract #2886

Semi LASER Localized Echo Planar Total Correlated Spectroscopic Imaging

Manoj Kumar Sarma1, Andres Saucedo1, Uzay E. Emir2, and M. Albert Thomas1
1Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 2School of Health Sciences, Purdue University – West Lafayette, West Lafayette, IL, United States

We implemented a semi-LASER localized total correlated spectroscopic imaging (EP-TOCSI) sequence on a 3T MRI scanner. Compared to L-COSY the coherence transfer 900 RF pulse was replaced by a spin-lock module consisting of adiabatic train of RF pulses using MLEV4 phase cycling; also, multi-voxel encoding included EPI read-out combined with phase-encoding. After evaluating the performance of the 4D EP-TOCSI sequence using a corn oil phantom, we investigated calf muscle of 2 healthy and 1 type 2 diabetic subjects. There were relayed cross peaks in addition to COSY cross peaks conventionally recorded by L-COSY or EP-COSI.

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