We implemented a semi-LASER localized total correlated spectroscopic imaging (EP-TOCSI) sequence on a 3T MRI scanner. Compared to L-COSY the coherence transfer 900 RF pulse was replaced by a spin-lock module consisting of adiabatic train of RF pulses using MLEV4 phase cycling; also, multi-voxel encoding included EPI read-out combined with phase-encoding. After evaluating the performance of the 4D EP-TOCSI sequence using a corn oil phantom, we investigated calf muscle of 2 healthy and 1 type 2 diabetic subjects. There were relayed cross peaks in addition to COSY cross peaks conventionally recorded by L-COSY or EP-COSI.
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