Abstract #2905

High-Resolution Whole-Brain 3D Magnetic Resonance Spectroscopic Imaging

Mohammed Goryawala¹, Sulaiman Sheriff¹, Ronald Ouwerkerk², Hari Hariharan³, Peter Barker⁴, Hyunsuk Shim⁵, and Andrew Maudsley¹

¹Radiology, University of Miami, Miami, FL, United States, ²Biomedical and Metabolic Imaging Branch, The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MD, United States, ³Center for Magnetic Resonance & Optical Imaging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ⁴Department of Radiology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA, United States

Whole-brain Magnetic Resonance Spectroscopic Imaging (MRSI) is an effective technique for non-invasive quantification of brain metabolite levels ^1-3 that can be used to create maps for the study of both regional or diffuse metabolic alterations in various pathologies. Improved spatial resolution can result in significantly better mapping but is often limited by the signal-to-noise ratio (SNR). This abstract presents a whole-brain 3D MRSI acquisition scheme that uses hypergeometric dual-band (HGDB) pulses for lipid suppression over the brain volume, real-time frequency drift correction, and novel post-processing methods to generate whole-brain metabolite maps in humans at 3T.

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