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Abstract #2907

Ex vivo whole brain metabolic fingerprinting at 7T - protocol optimization and preliminary results

Alexandra Lipka1,2, Lukas Hingerl1, Gilbert Hangel1, Eva Heckova1, Stanislav Motyka1, Verena Endmayr3, Romana Höftberger3, Simon Hametner4, Siegfried Trattnig1,2, and Wolfgang Bogner1,2
1Highfield MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, 3Institute for Neurology, Medical University of Vienna, Vienna, Austria, 4Center for Brain Research, Institute of Neuroimmunology, Medical University of Vienna, Vienna, Austria

MRS has rarely been applied for postmortem measurements except for single-voxel studies, which can be explained by the fact that rapid degradation of metabolite levels makes scanning of fresh specimen highly critical.SVS contrary to MRSI cannot cover whole affected regions, while pathological changes may not be visible on anatomical images, yet. To investigate changes ex-vivo, a true whole-brain MRSI approach is critical. Our study shows the potential of ultra-highfield whole-brain FID-MRSI for metabolic fingerprinting of fresh postmortem brains for correlation with histology, as the link between neurochemical changes and underlying cell-types in many demyelinating/neurodegenerative disorders is still not fully understood.

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