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Abstract #2909

Improvement of the selective multiple quantum coherence chemical shift imaging sequence for lactate imaging of lymphoma patients at 3T 

Seung-Cheol Lee1, Hari Hariharan1, Fernando Arias-Mendoza1, Gabor Mizsei1, Kavindra Nath1, Sanjeev Chawla1, Stephen J. Schuster1, Ravinder Reddy1, and Jerry Glickson1
1University of Pennsylvania, Philadelphia, PA, United States

Lactate is an important marker of tumor metabolism. We have previously reported the Hadamard slice selected, selective multiple quantum coherence chemical shift imaging sequence for a 3T clinical scanner to image lactate in the human body. Here we report modification and optimization of the sequence for reducing motion effect and increasing lipid suppression while retaining lactate. A coherence selection gradient ratio of a:-1:2 with nonzero a provided improved suppression of lipid resonances at 1.3 ppm and 0.9 ppm compared to the previous 0:-1:2 ratio. Optimization of RF pulses blocked occurrence of MQC between lipid 2.0 ppm and 5.3 ppm resonances.

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