Abstract #2920

Multi-site/Multi-vendor reproducibility of advanced MRS at 3T in a clinical cohort

James M Joers¹, Dinesh K Deelchand¹, Bin Guo², Lynn E Eberly², Young Woo Park¹, Adam Berrington³, Michal Povazan⁴, Andre van der Kouwe⁵, Khalaf Bushara⁶, Chiadi U Onyike⁷, Jeremy Schmahmann⁸, Peter B Barker^4,9, Eva Ratai⁵, and Gülin Öz¹

¹CMRR/Radiology, University of Minnesota, Minneapolis, MN, United States, ²Division of Biostatistics, University of Minnesota, Minneapolis, MN, United States, ³Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, ⁴Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵A.A. Martinos Center for Biomedical Imaging / Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States, ⁶Neurology, University of Minnesota Medical School, Minneapolis, MN, United States, ⁷Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, United States, ⁸Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, ⁹Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, MD, United States

The reproducibility of an advanced single voxel MRS protocol was tested in a clinical cohort and control subjects at 3T in a multi-site setting. A standardized MRS protocol was implemented on two MR system vendors (Siemens, Philips) over three sites. This protocol utilized automated voxel placement and an sLASER pulse sequence with identical radiofrequency waveforms, pulse durations, interpulse delays and gradient spoilers. Spectral quality, metabolite concentrations and test-retest reproducibility results from three voxels are reported from both the healthy control group and subjects with genetically-confirmed spinocerebellar ataxia type 3 (SCA3), a hereditary movement disorder.

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