Relationship between glutamate and GABA as well as their regional differences have not been much investigated. Focused on the posterior cingulate cortex (PCC), the primary motor area (M1) and the primary visual area (V1), this study found significantly higher glutamate concentration and E/I ratios at PCC than others, whereas GABA concentration was significantly higher at V1 than others. Region-wise correlation analysis between glutamate and GABA found statistically significant correlation only at M1 (r = 0.69, p = 0.0005). These differences may reflect difference in functional status at rest, but further investigation is required to clarify the reasons.
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