Indirect 13C measurements provide a large signal gain when compared to direct 13C-MRS. The regular J-difference editing (JDE) techniques are quite challenging to apply in the liver, as respiratory motion will result in imperfect subtraction of the huge overlapping 1H-[12C] signal, which hampers accurate quantification of the 1H-[13C] signals. Here, we demonstrated that the application of a BIlinear Rotation Decoupling filter prior to a regular JDE (STEAM-ACED) to pre-suppress the hindering 1H-[12C] signal, leads to a robust detection of the 1H-[13C] signal irrespective of respiratory motion. We showed an application of measuring 1H-[13C] lipid signals from the liver in vivo.
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