Meeting Banner
Abstract #3002

Hyperpolarized [1-13C]pyruvate MR spectroscopic imaging to detect metabolic changes in liver in a high-fat diet rat model of NASH and diabetes

Joao Piraquive Agudelo1, Shubhangi Agarwal1, Ting Sun1,2, Robert Bok1, Aras Mattis3,4, Jacquelyn Maher5,6, John Kurhanewicz1, Cornelius Von Morze7, and Michael Ohliger1,8
1Radiology and Biomedical Imaging, University of California San Francisco, San francisco, CA, United States, 2Peking Union Medical College Hospital, Peking, China, 3Department of Pathology, University of California San Francisco, San francisco, CA, United States, 4Liver center, University of California San Francisco, San Francisco, CA, United States, 5Department of Medicine, Division of Gastroenterology, University of California San Francisco, San francisco, CA, United States, 6Liver center, University of California San Francisco, San francisco, CA, United States, 7Biomedical Magnetic Resonance Laboratory, Washington University School of Medicine, St. Louis, MO, United States, 8Liver center, University of California San Francisco, San Franscisco, CA, United States

The present study was focused on using HP 13C MRSI to detect noninvasively metabolic changes in diabetic liver rats fed with a high-fat diet. Planned treatment is 20 weeks to induce NASH, but we present interim data at 4 weeks of treatment. Liver fat signal fraction was significantly increased. In animals, in which the fat and body weight increased, lactate/pyruvate ratio was significantly decreased. This might be explained by a stimulation of gluconeogenesis by high levels of fatty acids in the liver. Long-term monitoring allows us a better understanding of the metabolic changes in the progression from NAFLD diabetic rats.

This abstract and the presentation materials are available to 2020 meeting attendees and eLibrary customers only; a login is required.

Join Here