Abstract #3002

Hyperpolarized [1-13C]pyruvate MR spectroscopic imaging to detect metabolic changes in liver in a high-fat diet rat model of NASH and diabetes

Joao Piraquive Agudelo¹, Shubhangi Agarwal¹, Ting Sun^1,2, Robert Bok¹, Aras Mattis^3,4, Jacquelyn Maher^5,6, John Kurhanewicz¹, Cornelius Von Morze⁷, and Michael Ohliger^1,8

¹Radiology and Biomedical Imaging, University of California San Francisco, San francisco, CA, United States, ²Peking Union Medical College Hospital, Peking, China, ³Department of Pathology, University of California San Francisco, San francisco, CA, United States, ⁴Liver center, University of California San Francisco, San Francisco, CA, United States, ⁵Department of Medicine, Division of Gastroenterology, University of California San Francisco, San francisco, CA, United States, ⁶Liver center, University of California San Francisco, San francisco, CA, United States, ⁷Biomedical Magnetic Resonance Laboratory, Washington University School of Medicine, St. Louis, MO, United States, ⁸Liver center, University of California San Francisco, San Franscisco, CA, United States

The present study was focused on using HP ¹³C MRSI to detect noninvasively metabolic changes in diabetic liver rats fed with a high-fat diet. Planned treatment is 20 weeks to induce NASH, but we present interim data at 4 weeks of treatment. Liver fat signal fraction was significantly increased. In animals, in which the fat and body weight increased, lactate/pyruvate ratio was significantly decreased. This might be explained by a stimulation of gluconeogenesis by high levels of fatty acids in the liver. Long-term monitoring allows us a better understanding of the metabolic changes in the progression from NAFLD diabetic rats.

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