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Abstract #3020

Multi-compartment pH detection in healthy and tumour bearing mice using hyperpolarized deuterated [1,5-13C2]zymonic acid

Martin Grashei1, Sandra Sühnel1, Geoffrey Topping1, Elisabeth Bliemsrieder1, Stephan Düwel1, Christian Hundshammer1, and Franz Schilling1
1Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

Here, we demonstrate multi-compartment in vivo pH imaging in healthy and EL4-tumor bearing mice using deuterated hyperpolarized [1,5‑13C2, 3,6,6,6-D4]zymonic acid. Three pH-compartments of the healthy kidney (pHureter = 6.53±0.16, pHmedulla = 7.06±0.06 and pHcortex = 7.38±0.03) could be reliably detected using PRESS-voxel spectroscopy and chemical shift imaging. pH-imaging in mice bearing subcutaneous EL4-tumors allowed to identify one physiologic (pHphys = 7.39±0.05) and two acidic pH-compartments in the tumour (pHac,1 = 6.96±0.17, n=5), with the second pH-compartment being only present in subregions (pHac,2 = 6.62±0.10, n=5).

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