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Abstract #3030

Comparison of Selective Excitation and IDEAL for Chemical Shift Imaging of Hyperpolarized [1-13C]Pyruvate

Keith A Michel1, Christopher M Walker1, Matthew E Merritt2, and James A Bankson1
1Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, 2Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, United States

Imaging of hyperpolarized (HP) agents permits real-time non-invasive measurement of metabolic flux, however these experiments require specialized techniques for rapidly encoding chemical shift in a way that is sensitive metabolic signals that are often low SNR. The SNR performance of two chemical shift encoding methods commonly used for HP 13C MRI, IDEAL and spectral-spatial excitation pulses, were compared for a typical preclinical experiment imaging [1-13C]pyruvate at 7 T. The SNR of these two techniques were found to be equivalent in numerical simulation, while the SNR measured for IDEAL was ~30% greater than for spectral-spatial pulses in a thermal phantom experiment.

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