Abstract #3042

In vivo evaluation of metabolic response to dobutamine stimulation in ischemic rat hearts using hyperpolarized 13C-pyruvate

Gaurav Sharma¹, Alexander Funk¹, Xiaodong Wen¹, Crystal Harrison¹, Nesmine Maptue¹, Craig R. Malloy^1,2,3, A. Dean Sherry^1,3,4, and Chalermchai Khemtong^1,3

¹Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, ²Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States, ³Radiology, UT Southwestern Medical Center, Dallas, TX, United States, ⁴Chemistry, The University of Texas at Dallas, Richardson, TX, United States

Heart failure due to ischemic coronary artery disease is a leading cause of morbidity and mortality. Metabolic assessment of myocardium could be important for assessing myocardial ischemia in patients. This study evaluated in vivo metabolism of hyperpolarized ¹³C-pyruvate in ischemia rat hearts under normal and elevated workload by dobutamine stimulation. Decreased production of bicarbonate was observed in hearts with ischemic myocardium compared to control hearts. Dobutamine stimulation lowered bicarbonate production in control hearts but did not change the appearance of bicarbonate signals in ischemic group.

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