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Abstract #3042

In vivo evaluation of metabolic response to dobutamine stimulation in ischemic rat hearts using hyperpolarized 13C-pyruvate

Gaurav Sharma1, Alexander Funk1, Xiaodong Wen1, Crystal Harrison1, Nesmine Maptue1, Craig R. Malloy1,2,3, A. Dean Sherry1,3,4, and Chalermchai Khemtong1,3
1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 2Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States, 3Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 4Chemistry, The University of Texas at Dallas, Richardson, TX, United States

Heart failure due to ischemic coronary artery disease is a leading cause of morbidity and mortality. Metabolic assessment of myocardium could be important for assessing myocardial ischemia in patients. This study evaluated in vivo metabolism of hyperpolarized 13C-pyruvate in ischemia rat hearts under normal and elevated workload by dobutamine stimulation. Decreased production of bicarbonate was observed in hearts with ischemic myocardium compared to control hearts. Dobutamine stimulation lowered bicarbonate production in control hearts but did not change the appearance of bicarbonate signals in ischemic group.

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