Abstract #3051

In Vivo T2* Mapping of Hyperpolarized 13C-Labeled Metabolites Using a Metabolite-Selective Multi-Echo Spiral Imaging Sequence

Junjie Ma¹, Edward P. Hackett¹, and Jae Mo Park^1,2,3

¹Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, ²Radiology, UT Southwestern Medical Center, Dallas, TX, United States, ³Electrical Engineering, UT Dallas, Richardson, TX, United States

Multi-echo ¹³C spiral imaging sequence combined with a spectral-spatial radiofrequency pulse is implemented for sequential imaging of hyperpolarized [¹³C]bicarbonate, [1-¹³C]lactate and [1-¹³C]pyruvate. From the multi-echo ¹³C images of each metabolite in vivo T₂* maps are generated. The pulse sequence was tested with a ¹³C-phantom and applied to measure T₂*s of hyperpolarized [1-¹³C]pyruvate and the products in rat heart in vivo.

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