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Abstract #3051

In Vivo T2* Mapping of Hyperpolarized 13C-Labeled Metabolites Using a Metabolite-Selective Multi-Echo Spiral Imaging Sequence

Junjie Ma1, Edward P. Hackett1, and Jae Mo Park1,2,3
1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 2Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 3Electrical Engineering, UT Dallas, Richardson, TX, United States

Multi-echo 13C spiral imaging sequence combined with a spectral-spatial radiofrequency pulse is implemented for sequential imaging of hyperpolarized [13C]bicarbonate, [1-13C]lactate and [1-13C]pyruvate. From the multi-echo 13C images of each metabolite in vivo T2* maps are generated. The pulse sequence was tested with a 13C-phantom and applied to measure T2*s of hyperpolarized [1-13C]pyruvate and the products in rat heart in vivo.

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