Abstract #3053

The Best Combination of Genes for Genetic Reporter of Cellular Level MR Imaging

Naoya Hayashi^1,2, Junichi Hata^2,3, Tetsu Yoshida², Yawara Haga^1,2, Hideyuki Okano^2,4, Hirotaka James Okano³, and Akira Furukawa¹

¹Department of Radiological Sciences, Human Health Sciences, Tokyo Metropolitan University Graduate School, Tokyo, Japan, ²Laboratory for Marmoset Neural Architecture, Center for Brain Science, RIKEN, Saitama, Japan, ³Division of Regenerative Medicine, The Jikei University School of Medicine, Tokyo, Japan, ⁴Department of Physiology, Keio University School of Medicine, Tokyo, Japan

We examined which gene we should transduce for genetic reporter for Magnetic Resonance Imaging (MRI) by comparing T1 or T2 values of the cells followed by exposure to MnCl₂ or Holo-transferrin. We identified the cell which has the shortest T1 or T2 values and it indicates that they can be useful genetic reporter for T1 Weighted Imaging (T1WI) or T2 Weighted Imaging (T2WI).

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