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Abstract #3053

The Best Combination of Genes for Genetic Reporter of Cellular Level MR Imaging

Naoya Hayashi1,2, Junichi Hata2,3, Tetsu Yoshida2, Yawara Haga1,2, Hideyuki Okano2,4, Hirotaka James Okano3, and Akira Furukawa1
1Department of Radiological Sciences, Human Health Sciences, Tokyo Metropolitan University Graduate School, Tokyo, Japan, 2Laboratory for Marmoset Neural Architecture, Center for Brain Science, RIKEN, Saitama, Japan, 3Division of Regenerative Medicine, The Jikei University School of Medicine, Tokyo, Japan, 4Department of Physiology, Keio University School of Medicine, Tokyo, Japan

We examined which gene we should transduce for genetic reporter for Magnetic Resonance Imaging (MRI) by comparing T1 or T2 values of the cells followed by exposure to MnCl2 or Holo-transferrin. We identified the cell which has the shortest T1 or T2 values and it indicates that they can be useful genetic reporter for T1 Weighted Imaging (T1WI) or T2 Weighted Imaging (T2WI).

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