Abstract #3103

To Evaluate Effect of Interpolation Methods for B0 inhomogeneity correction on computation of CEST MRI Contrast in Human Brain at 3T and 7T

Anup Singh^1,2, Ayan Debnath^1,3, Rakesh Kumar Gupta⁴, and Ravinder Reddy³

¹Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India, ²Biomedical Engineering, AIIMS, New Delhi, India, ³Radiology, University of Pennsylvania, Philadelphia, PA, United States, ⁴Radiology, Fortis Memorial Research Institute, Gurugram, India

CEST MRI provides high resolution mapping of molecules such as Glutamate, Creatine, labile proteins/peptide, etc. CEST MRI contrast computation using asymmetry analysis require interpolation of data at different frequency offsets for B0 inhomogeneity corrections. In this study, different interpolation methods such as polynomial, cubic, spline and smoothingspline were compared for B0 inhomogeneity correction of various CEST contrasts(GluCEST-w, APT-w, CrCEST-w) at different field strength (3T, 7T). The 2nd and 3rd degree polynomial interpolations provided better B0 inhomogeneity correction for in vivo data from human brain. Polynomial interpolations for APT-w also improved differentiation of high-grade-glioma and low-grade-glioma tumors at 3T.

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