Multi-slice chemical exchange saturation transfer (CEST) imaging is difficult to use for clinical studies because data acquisition of the full z-spectrum is time-consuming. To accelerate the scan time for obtaining multi-slice CEST imaging, we applied the compressed sensing (CS) and sensitivity encoding (SENSE) technique (CS-SENSE) to 3D CEST imaging. The 3D CEST imaging combined with CS-SENSE was obtained without reducing the image contrast of the 2D CEST imaging. Moreover, 10 slice CEST images could be acquired in approximately 7 minutes including B0 map. 3D CEST imaging combined with CS-SENSE was shown to be useful for clinical study.