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Abstract #3119

Inulin as a biodegradable contrast agent for CEST MRI

Anina Seidemo1, Malte Knutsson2, Patrick M. Lehmann1, Pia C. Sundgren3,4, Anthony Aletras5,6, Peter C.M. van Zijl7,8, and Linda Knutsson1,7
1Department of Medical Radiation Physics, Lund University, Lund, Sweden, 2Procivitas, Malmö, Sweden, 3Department of Diagnostic Radiology, Lund University, Lund, Sweden, 4Lund University Bioimaging Center, Lund University, Lund, Sweden, 5Department of Clinical Physiology, Clinical Sciences, Lund University and Lund University Hospital, Lund, Sweden, 6Laboratory of Computing and Medical Informatics, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece, 7Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 8F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

GlucoCEST (chemical exchange saturation transfer imaging using glucose as a contrast agent) has shown potential in tumor imaging. However, glucose enters cells and is rapidly metabolized, leading to disappearance of the glucoCEST signal over time. Inulin, a polysaccharide, is non-toxic and acts like an intravascular tracer when injected intravenously. A phantom including both glucose and inulin at different pH and concentrations was scanned at 3T to investigate the potential of inulin as a CEST agent. This study indicates that inulin shows CEST contrast comparable to glucose on a per-OH-unit basis and has potential as a biodegradable CEST agent.

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