Abstract #3119

Inulin as a biodegradable contrast agent for CEST MRI

Anina Seidemo¹, Malte Knutsson², Patrick M. Lehmann¹, Pia C. Sundgren^3,4, Anthony Aletras^5,6, Peter C.M. van Zijl^7,8, and Linda Knutsson^1,7

¹Department of Medical Radiation Physics, Lund University, Lund, Sweden, ²Procivitas, Malmö, Sweden, ³Department of Diagnostic Radiology, Lund University, Lund, Sweden, ⁴Lund University Bioimaging Center, Lund University, Lund, Sweden, ⁵Department of Clinical Physiology, Clinical Sciences, Lund University and Lund University Hospital, Lund, Sweden, ⁶Laboratory of Computing and Medical Informatics, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece, ⁷Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁸F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

GlucoCEST (chemical exchange saturation transfer imaging using glucose as a contrast agent) has shown potential in tumor imaging. However, glucose enters cells and is rapidly metabolized, leading to disappearance of the glucoCEST signal over time. Inulin, a polysaccharide, is non-toxic and acts like an intravascular tracer when injected intravenously. A phantom including both glucose and inulin at different pH and concentrations was scanned at 3T to investigate the potential of inulin as a CEST agent. This study indicates that inulin shows CEST contrast comparable to glucose on a per-OH-unit basis and has potential as a biodegradable CEST agent.

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