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Abstract #3133

One Minute Whole-Brain Magnetization Transfer Ratio Imaging with Intrinsic B1-Correction 

Roya Afshari1,2, Francesco Santini1,2, Rahel Heule3, Craig H. Meyer4, Josef Pfeuffer5, and Oliver Bieri1,2
1Division of Radiological Physics,Department of Radiology, University Hospital Basel, University of Basel, Basel, Switzerland, 2Department of Biomedical Engineering, University of Basel, Basel, Switzerland, 3High Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 4Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, 5Siemens Healthcare, Application Development, Erlangen, Germany

Magnetization transfer (MT), reflecting the exchange of magnetization between mobile and bound protons, has shown good potential for the diagnosis and prognosis of various neurological disorders, such as multiple sclerosis. Frequently, MT effects are assessed by measuring the contrast between two scans performed with and without saturation of the bound pool protons. Evidently, saturation is affected by B1 inhomogeneity and should be accounted for. In this work, we report on a very rapid one-minute whole-brain magnetization transfer ratio (MTR) imaging method offering intrinsic B1-correction.

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