Abstract #3133

One Minute Whole-Brain Magnetization Transfer Ratio Imaging with Intrinsic B1-Correction

Roya Afshari^1,2, Francesco Santini^1,2, Rahel Heule³, Craig H. Meyer⁴, Josef Pfeuffer⁵, and Oliver Bieri^1,2

¹Division of Radiological Physics,Department of Radiology, University Hospital Basel, University of Basel, Basel, Switzerland, ²Department of Biomedical Engineering, University of Basel, Basel, Switzerland, ³High Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, ⁴Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, ⁵Siemens Healthcare, Application Development, Erlangen, Germany

Magnetization transfer (MT), reflecting the exchange of magnetization between mobile and bound protons, has shown good potential for the diagnosis and prognosis of various neurological disorders, such as multiple sclerosis. Frequently, MT effects are assessed by measuring the contrast between two scans performed with and without saturation of the bound pool protons. Evidently, saturation is affected by B₁ inhomogeneity and should be accounted for. In this work, we report on a very rapid one-minute whole-brain magnetization transfer ratio (MTR) imaging method offering intrinsic B₁-correction.

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