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Abstract #3182

Assessment of the sensitivity of Phase-Only Helmholtz-EPT to spatially-dependent conductivity changes using a glioma-brain-phantom

Lucia Bossoni1, Andrew Webb1, Loes Huijnen2, Remco Overdevest2, and Wyger Brink1
1Leiden University Medical Center, Leiden, Netherlands, 2Leiden University, Leiden, Netherlands

Phase-only Helmholtz-Electrical Property Tomography (PO-HEPT) has recently shown promise for the detection and grading of diffuse glioma. However, a brain glioma is usually located away from the centre of the brain where the transceive phase and phase-only approximations used in reconstruction may not be valid. Here we assessed the sensitivity of PO-HEPT in an anatomically realistic brain phantom where an off-centre glioma-compartment was incorporated, and using a clinically applicable MR sequence. Our results show that while the accuracy of the PO-HEPT deteriorates, its sensitivity is mostly unaffected, thus allowing correlative studies of tumour grading.

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