Abstract #3189

Acquisition-weighted MR Current Density Imaging (AW-MRCDI) improves sensitivity and spatial resolution

Cihan Göksu^1,2, Lars G. Hanson^1,3, Fróði Gregersen^1,3,4, Klaus Scheffler^2,5, and Axel Thielscher^1,3

¹Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Hvidovre, Denmark, ²High-Field Magnetic Resonance Center, Max-Planck-Institute for Biological Cybernetics, Tübingen, Germany, ³Center for Magnetic Resonance, DTU Health Tech, Technical University of Denmark, Kgs. Lyngby, Denmark, ⁴Sino-Danish Center for Education and Research, Aarhus, Denmark, ⁵Department of Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany

Exact knowledge of currents flowing inside the human brain is important for several neuroscientific applications. MRCDI combines MR with externally injected weak currents, and uses measurements of the current-induced magnetic field to estimate spatial current distribution. The method’s accuracy highly depends on the sensitivity and spatial resolution of the field measurements. Here, we improve the currently most sensitive MRCDI method based on steady-state free precession free induction decay (SSFP-FID) by using an acquisition-weighted scheme (AW-MRCDI). We compared weighted and conventional schemes by phantom experiments. AW-MRCDI demonstrated 59% increase in sensitivity and significantly improved the spatial resolution.

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