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Abstract #3192

An in-vivo study to provide reference conductivity values of the human brain at 3T

Stefano Mandija1,2, Petar Petrov3, Jord Vink3, Sebastian Neggers3, and Cornelis A.T. van den Berg1,2
1Computational Imaging Group for MR diagnostic and therapy, Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands, 2Department of Radiotherapy, Division of Imaging and Oncology, University Medical Center Utrecht, Utrecht, Netherlands, 3Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, Netherlands

First in-vivo brain conductivity reconstructions have been recently published. However, a large variation in the reconstructed conductivity values is reported and these results substantially differ from ex-vivo measurements. Given this lack of agreement, we performed an in-vivo study on eight healthy subjects to provide reference brain conductivity values. The measured in-vivo mean WM and GM conductivity values verify for the first time the literature values measured ex-vivo, while the reconstruction accuracy was verified in simulation settings. The presented values can therefore be used as a verified in-vivo reference for future studies, where new reconstruction algorithms are tested in-vivo.

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