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Abstract #3201

Improved Susceptibility Weighted Imaging using bipolar multi-echo acquisition and optimized processing of phase and magnitude data: CLEAR-SWI  

Simon Daniel Robinson1,2,3, Gilbert Hangel2, Beata Bachrata2, Andreas Ehrmann2, Siegfried Trattnig2, Christian Enzinger3, Markus Barth1, and Korbinian Eckstein2
1Centre for Advanced Imaging, University of Queensland, Brisbane, Australia, 2Medical University of Vienna, Vienna, Austria, 3Medical University of Graz, Graz, Austria

We describe a systematic optimization of gradient-echo-based SWI at 7T, encompassing SNR in single-echo vs multi-echo acquisitions (both monopolar and bipolar), coil combination, phase unwrapping, filtering, echo weighting and correction of image inhomogeneity. The improvement achieved with the resulting Contrast-weighted, Laplace-unwrapped, bipolar multi-Echo, ASPIRE-combined, homogeneous, improved Resolution SWI (or CLEAR-SWI) is compared to ‘Standard’ single-echo, Homodyne filtered SWI in healthy subjects and patients. CLEAR-SWI reduces signal dropout, eliminates wrap artefacts and provides multi-echo phase and magnitude data for R2* mapping and QSM. Applied clinically, it provides improved visibility of multiple sclerosis lesions and the composition of tumors.

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