Abstract #3204

Phantom Validation of Simultaneous Mapping of PDFF, R2*, and Susceptibility

Collin J Buelo^1,2, Ruiyang Zhao^1,2, Ante Zhu^2,3, Scott B. Reeder^1,2,3,4,5, and Diego Hernando^1,2,3

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Radiology, University of Wisconsin-Madison, Madison, WI, United States, ³Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁴Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁵Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

Chemical shift-encoded (CSE) MRI can be used to simultaneously obtain multi-parametric maps, including R2*, proton density fat fraction (PDFF), and tissue susceptibility, to aid in the diagnosis of diffuse liver disease. However, the presence of fat in tissue can confound both R2* and B0 field estimation and consequently quantitative susceptibility mapping (QSM). To validate this multi-parametric mapping, comparison of quantitative maps to phantoms with known iron concentrations were performed. This work demonstrated the feasibility of accurate PDFF mapping, and R2* and susceptibility measurements that are linearly dependent on both iron and fat concentration.

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