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Abstract #3227

A Novel Chemical Shift-Selective Fat Saturation RF Pulse Design with Robustness to B0/B1 Inhomogeneity: A Demonstration on Breast MRI at 3T

Feng Xu1,2, Wenbo Li1,2, Dapeng Liu1,2, Dan Zhu3, Kelly Myers1, Michael Shär1, and Qin Qin1,2
1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Biomedical Engineering, Johns Hopkins University, School of Medicine, Baltimore, MD, United States

Chemical shift-selective fat saturation (CHESS) is the most commonly used fat suppression technique for clinical MRI. Conventional Gaussian-shaped pulses are sensitive to B1 inhomogeneity and their wide transitional band can be affected by B0 off-resonance. Uniform fat saturation across a large field of view (FOV) is especially challenging for body and breast MRI at 3T. Here, we designed a novel frequency-selective RF pulse based on the optimal control theory with robustness to a targeted wide range of B0/B1 conditions. Its superior performance than the regular ones was demonstrated using T1-weighted sequences with whole-breast coverage.

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