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Abstract #3258

Perfusion Estimates of Fast Dynamic Contrast Enhanced MRI Correlates with Dynamic Susceptibility Contrast in Brain Metastases Follow-up

Benoit Bourassa-Moreau1, Réjean Lebel1, Ella Benzaquen2, Ismaël Labbé3, Guillaume Gilbert4, David Mathieu3, and Martin Lepage1
1Centre d’imagerie moléculaire de Sherbrooke, Département de médecine nucléaire et radiobiologie, Université de Sherbrooke, Sherbrooke, QC, Canada, 2Département radiobiologie diagnostique, Université de Sherbrooke, Sherbrooke, QC, Canada, 3Service de neurochirurgie, Département de chirurgie, Université de Sherbrooke, Sherbrooke, QC, Canada, 4MR Clinical Science, Philips Healthcare Canada, Markham, ON, Canada

Perfusion MRI is routinely used for brain tumor diagnosis and treatment follow-up. This work compares the performance of the standard dynamic susceptibility contrast sequence against a new fast dynamic contrast-enhanced sequence for brain metastasis follow-up after stereotactic radiosurgery. This new sequence enables the simultaneous measurement of blood brain barrier permeability that could help differentiate tumor recurrence and pseudo-progression. Our preliminary results show a correlation between relative cerebral blood volume estimates from both methods. A trend towards significance after analysis of thirteen lesions is expected to reach significance after inclusion of the remainder of our cohort.

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