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Abstract #3301

Improving Robustness to Field Imperfections for Velocity-Selective Inversion prepared Arterial Spin Labeling through Dynamic Phase-Cycling

Dapeng Liu1,2, Wenbo Li1,2, Feng Xu1,2, Dan Zhu3, Taehoon Shin4,5, and Qin Qin1,2
1Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Division of Mechanical and Biomedical Engineering, Ewha Womans University, Seoul, Korea, Republic of, 5Department of Medicine, Case Western Reserve University, Cleveland, OH, United States

In Fourier-transform based velocity-selective inversion (FT-VSI) arterial spin labeling (ASL), either velocity-insensitive or velocity-compensated waveforms could be applied for control modules. Under poor B0/B1 conditions with inefficient refocusing, the scheme with velocity-insensitive control is susceptible to strong false signal but maintained high labeling efficiency, while the scheme with velocity-compensated control has poor velocity-selective labeling profiles. This study overcome these problems by proposing a dynamic phase-cycling scheme based on velocity-insensitive waveform and improve the robustness to B0/B1 field inhomogeneities for VSI ASL. Simulation, phantom and brain ASL scans were conducted for demonstration.

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