Simultaneous fat-water EPI-MR elastography imaging was developed for acquisition of the brain (water) and skull (bone marrow fat) MRE motion. Compared to our previous dual-saturation and dual-sensitivity motion encoding (DSDM) technique, the proposed method minimize the EPI distortion and misalignment between skull and brain. This technique could offer a unique opportunity to quantify the skull-brain mechanical decoupling performance modulated by the pia-arachnoid complex, and its potential alterations in response to repetitive head impacts (RHI) in our future studies.
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