Large head motion induces different local magnetic-field inhomogeneities, even if the field of view is corrected prospectively. In this work, we implemented and evaluated a diffusion-weighted dual-echo EPI sequence that prospectively corrects for motion using real-time measurements from an optical tracker and uses echoes acquired with reversed phase-encoding to correct for the distortions resulting from the induced local magnetic field inhomogeneities. We evaluated our motion and distortion correction framework in volunteer experiments undergoing controlled motion, and in pediatric patients undergoing routine MRI. Prospective motion correction using our proposed method produced high-quality diffusion parameter maps in all volunteer and patient scans.
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