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Abstract #3373

Relaxation-Time Selective Imaging Using the Inverse Z-transform

Seong-Min Kim1, Phuong Anh Chu Dang1, Sehong Oh2,3, and Jang-Yeon Park1,4
1Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of, 2Division of Biomedical Engineering, Hankuk University of Foregn Studies, Yongin, Korea, Republic of, 3Imaing Institute, Cleveland Clinic Foundation, Cleveland, OH, United States, 4Center for Neuroscience Imaging Research, Suwon, Korea, Republic of

There have been many attempts to separate mixed relaxation-time decays. Among them, some approaches do not assume the number of exponential decays a priori for the analysis of multiple-component decay signals. However, they are sensitive to ill conditions and have a poor resolving ability in terms of decay constants. In this study, a new method is proposed that can analyze multiple T2 decays with high resolution using the inverse Z-transform, which was demonstrated in simulation and in vivo human brain experiment. T2-selective images were also presented and used for myelin-water fraction mapping and deep brain-tissue segmentation.

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