Abstract #3373

Relaxation-Time Selective Imaging Using the Inverse Z-transform

Seong-Min Kim¹, Phuong Anh Chu Dang¹, Sehong Oh^2,3, and Jang-Yeon Park^1,4

¹Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of, ²Division of Biomedical Engineering, Hankuk University of Foregn Studies, Yongin, Korea, Republic of, ³Imaing Institute, Cleveland Clinic Foundation, Cleveland, OH, United States, ⁴Center for Neuroscience Imaging Research, Suwon, Korea, Republic of

There have been many attempts to separate mixed relaxation-time decays. Among them, some approaches do not assume the number of exponential decays a priori for the analysis of multiple-component decay signals. However, they are sensitive to ill conditions and have a poor resolving ability in terms of decay constants. In this study, a new method is proposed that can analyze multiple T₂ decays with high resolution using the inverse Z-transform, which was demonstrated in simulation and in vivo human brain experiment. T₂-selective images were also presented and used for myelin-water fraction mapping and deep brain-tissue segmentation.

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