The purpose of this study was to evaluate an efficient, free-breathing, whole-heart 4D flow CS protocol in a cohort of 21 healthy controls. The CS technique was evaluated for internal self-consistency by comparing net flow through various cardiac structures. In addition, cine imaging was performed and used to calculate left ventricular (LV) stroke volume (SV) for comparison to net flow in the ascending aorta. CS whole-heart 4D flow was acquired in 5:23 ± 0:51 minutes. Input and output flow, and LV stroke volume and ascending aorta net volume with 4D flow were significantly (p<0.05) correlated for all comparisons.