A novel approach for mitigating artifacts from localized motion of the eye, during interleaved multi-shot diffusion weighted imaging, is presented. A 2D cylindrical spatial saturation pulse is used to suppress signal from the orbit region, thereby significantly suppressing the ghost artifacts from eye movement in low b-value images. The saturation being localized to the orbit region does not influence the surrounding tissues. Placement of such a cylindrical pulse on the orbit region is relatively straight forward. In addition, the total scan time is not significantly affected by the cylindrical pulse saturation.