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Abstract #3409

Fast library-driven approach for the two-step iterative calculation of the voxel spread function

Jie Wen1, Dmitriy A Yablonskiy2, Alexander L Sukstanskii2, Feiyan Zeng1, and Ying Liu1
1Radiology, The First Affiliated Hospital of USTC, Hefei, China, 2Radiology, Washington University in St. Louis, St. Louis, MO, United States

Macroscopic B0 magnetic field inhomogeneity adversely affects Gradient-Recalled-Echo (GRE) MRI images. A previously introduced voxel spread function (VSF) method has been proposed to correct for these adverse effects if data are acquired using multi-GRE (mGRE) sequences. The method accounts for both, through-slice and in-slice field inhomogeneities and accounts for between-voxel signal propagation effects. The direct voxel-wise VSF calculation requires long computation time. We propose a library-driven approach for the VSF calculation that significantly reduces computation time, thus providing a platform for the applications of mGRE-based quantitative techniques in clinical practices.

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