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Abstract #3415

Compensating Diffusion Bias of Quantitative T2 mapping on High-Field MRI Scanners

Natalie Bnaiahu1, Ella Wilczynski1, Shir Levy2, Noam Omer1, Tamar Blumenfeld-Katzir1, and Noam Ben-Eliezer1,3,4
1Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel, 2School of Chemistry, Tel Aviv University, Tel Aviv, Israel, 3Sagol school of Neuroscience, Tel Aviv University, Tel Aviv, Israel, 4Center for Advanced Imaging Innovation and Research, New York, NY, United States

On high-field scanners, strong imaging gradients induce spurious diffusion signal decay, which distorts qT2 calculation. By modeling the pulse sequence gradients and coherence pathways, an effective b value was calculated to assess signal attenuation caused by diffusion. ADC values were measured, extensive phantom scans and in-vivo experiments were performed using the MSME protocol with varied voxel sizes to examine the effect and the solution. Before correction T2 values were short with high variability across different voxel sizes, after correction T2 values increased and became more accurate and consistent. Tissue properties also influenced the correction as their ADC varies.

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