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Abstract #3417

Diffusion spoiling for fast steady-state gradient echo imaging of the human brain using a 300 mT/m gradient system

Kerrin J Pine1, Luke J Edwards1, and Nikolaus Weiskopf1
1Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

In gradient echo imaging sequences, transverse coherences persisting across repetitions must be managed to avoid large variations in the steady state signal. Ultra-high amplitudes for gradient spoiling can be effective, however, conventional human MR scanners do not achieve the necessary gradient amplitudes. By using a 3T Connectom MRI scanner with a 300 mT/m gradient amplitude, we demonstrate that by operating in the diffusion spoiling regime, it is now possible to eliminate the contribution of unwanted transverse magnetization to the steady state by gradient spoiling alone. It can serve as a reference standard for validating spoiling schemes and for R1 quantification.

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