N/2 ghosts in EPI result from consistent discrepancies between readouts with positive and negative polarities. We present 3D EPI with scrambled readout polarities as a strategy to reduce the coherence of N/2 ghosts in 4D x-f space and reduce their impact on quantitative analyses (e.g., motion tracking or resting state fMRI). We demonstrate that the method can produce either individual volumes with N/2 ghost energy spread out in the partition direction, or complete 4D x-f data with ghosts spread in both partition and frequency directions.
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